A transplant is an operation which entails replacing tissues or organs, the functions of which have been reduced to the point where living is not possible anymore and all the other treatment methods have been depleted. A lot of patients who, in the best-case scenario, had the possibility of either living an arduous and restricted life or expecting their deaths, by undergoing organ transplant are able to recover and live a normal life. The first step in organ transplant is explant. Explant refers to the act of removing organs or tissues from the donor in order to transplant them into another person. The goal of every explant is for it to be multi-organ. When it comes to treating patients, the highest step in today’s medicine are namely organ and tissue explant and transplant. Before receiving an organ, it is important to prove brain death. The main issue in the transplant process is the lack of organs. The first successful organ transplant was conducted more than thirty years ago. Introducing cyclosporine into therapy has brought a great progress regarding the transplant rejection, leading to the development of kidney, liver, and heart transplants. One of the professionals in the organ transplant team is a transplant nurse. The most challenging part of the explant is preparing and caring for the donor, and it is in this part of the operation that the nurse has the key role. The nurse is included in the process from start to finish, from preparing the patient prior to the operation and helping the surgeon during the transplant, to taking care of the patient after the procedure and making sure that the body does not reject the transplanted organ. As well as that, the nurses work with the donors, they educate them on the transplant process, and answer any possible questions regarding the procedure.