Ankylosing spondylitis, also known as Behterew's disease, is a progressive, chronic, and inflammatory, systemic, and rheumatic disease. In this type of disease, connective tissue ossification occurs. It primarily involves the axial skeleton, but it can also involve peripheral joints outside the joint structure and the location of the bone tendon, or enthesus. The appearance of the spine in this disease is often reminiscent of a bamboo stick. As for the etiology, ankylosing spondylitis mostly occurs in males in the second and third decades of life, in 90% to 95% of cases the incidence of the disease is associated with HLA-B27 antigen. The most common inflammatory change in this disease is enthesitis. With enthesitis, edema and bone erosion occur, and with the progression of the disease, ossification occurs and eventually fibrous and bone ankylosis. In the initial stage, the main symptom is pain that occurs in the lumbosacral area. In the diagnosis of ankylosing spondylitis, CT, MR, X-rays, laboratory findings, etc. are used. Before starting rehabilitation, it is important to make a physiotherapy assessment of the patient, which includes anamnesis, observation, various measurements, tests, specific tests for AS. The most important component of rehabilitation is kinesitherapy, which includes breathing exercises, strengthening, stretching and mobility of the spine, as well as fitness exercises. In addition to kinesitherapy, other types of therapy are used, such as hydrotherapy, balneotherapy, electrotherapy, ultrasound, phototherapy. Importance is also given to educating the patient and his environment about the disease itself and the way of life and performing the daily life activities of a patient suffering from ankylosing spondylitis.