Chronic wounds are one of the most demanding medical challenges and represent a significant burden for the health care system. They severely impair the quality of life of the patient as well as his/her families and affect economic stability. Wounds that do not heal within the predicted period correlated with the etiology and localisation of the wound, and within the shortest period of 4 to 6 weeks are called chronic wounds. Given etiological factors, the chronic wound requires a multidisciplinary approach, with a great effort by medical staff in order to treat the chronic wound as efficiently, simpler, painless as possible and cheaper for health funds. Treatment of wounds with treatment of negative pressure with vacuum-boosted closure showed markedly good results when treating chronic wounds. It is a special device that generates negative pressure below 125 millimetres of mercury in the wound itself, and it operates through special sponges applied in the wound and according to it are formed. The secretion from the wound is drained into a sealed container inside the apparatus by a special system. Negative pressure provides optimal amount of liquid content in the early and capillary flow in order to improve capillary perfusion. This provides ideal conditions for wound healing and removes dead tissue and bacteria. The treatment system of wounds with negative pressure improves tissue perfusion within the wound and in the surrounding tissue, reduces oedema and the number of bacteria in the wound. The need for frequent wound clotting and thus exposure to the risk of infection is reduced, as the wound is dry and sterile covered. Due to the aforementioned positive effects, treatment with negative blood pressure is very commonly used for skin transplants in chronic wounds and significantly reduces the possibility of transplant rejection. The resulting successful skin transplantation greatly accelerates the course of treatment and often leads to complete healing.