Polyneuropathy is a symmetrical damage that affects several groups of nerves with a wide range of symptoms, depending on the severity of the damage and the nerves that are damaged. Damage affects the motor, sensory and autonomic nerve fibers. They have a multitude of causes, many of which can be diagnosed by careful clinical and physiotherapeutic assessment. Disorders can be genetically determined, metabolic, toxic, infectious and immune. According to the course of the disease, we divide them into: acute, subacute and chronic. Symptoms first appear in the distal parts of the lower extremities, and with further development of the disease they spread to the upper extremities. The onset of symptoms varies depending on the type of nerve fibers involved, but also on the stage of the disease. Sensory disorders in the form of paresthesias (burning, tingling, prickling) are manifested. With the progression of sensory symptoms, motor symptoms also occur, in which muscle atrophy and weakened tendon reflexes occur. Physiotherapy assessment includes taking a medical history, inspection, observation, palpation, examination of voluntary motor skills, reflexes and assessment of sensations and activities of daily life. The obtained data create a physiotherapeutic treatment, the focus of which is on the implementation of kinesitherapy, hydrotherapy and the application of electrotherapeutic procedures.