Down syndrome is a genetic disorder that occurs when chromosomes are transferred incorrectly. There are three types of Down syndrome: classical type, mosaic type and translocation type. Older age of the mother represents one of the most common risks for the development of a fetus with Down syndrome. The characteristics of the mentioned syndrome are individual and are mostly small ears, wide hands and specifically set eyes. In addition, it is not uncommon to have low vision, hearing loss, muscle weakness, etc. In order to start rehabilitation on time, it is important to first make a correct diagnosis, which in this case may include processes such as: amniocentesis, ultrasound diagnostics and the fish method. Considering the combinations of possible conditions in the form of cardiac, endocrinological, digestive, locomotor, sensory and psychological difficulties, the functional status is determined. Treatment includes teamwork consisting of a physiotherapist, cardiologist, endocrinologist, speech therapist, orthopedist, ophthalmologist, psychologist and all other necessary health professionals depending on the patient's health condition. Physiotherapy, along with other medical interventions, plays an important role in the treatment of Down's syndrome. Physiotherapy for this disease can include procedures such as: sensory integration, neurodevelopmental technique, movement therapy, hippotherapy, Halliwick therapy, Vojta therapy, etc. Physiotherapy processes aim to optimize motor skills and minimize the development of unnatural compensatory movements. It is important to approach each child individually, considering the variety of difficulties that can occur with the above diagnosis. The main goal of treating children with Down syndrome is to facilitate their growth and to enable them to fully realize their potential. Quality treatment results require the involvement of the parents, as well as the best possible motivation of the child.