The distal part of the femur and the proximal part of the tibia form the articular surfaces of the largest joint in the body, the knee. Knee is necessary for walking and daily movement, and therefore for participation in most of the sports. Demanding loads to which the knee joint is exposed in everyday situations and trainings can lead to overloading of soft tissues and the development of overuse injurie due to daily microtraumas of the joint. Microtraumas affecting anterior structures are manifested in conditions such as patellar tendinopathy, patellofemoral pain syndrome, Osgood Schlatter’s disease, Hoff’s syndrome, and Sinding-Larsen-Johansson syndrome. Overuse of the anterior side of the knee occurs over repeated sudden contractions of the quadriceps, insufficient coordination of the extensor apparatus or excessive tension of the quadriceps. It manifests itself in running, jumping, sports such as basketball, football, volleyball, cycling, skiing and tennis. In addition to the anterior structures in the knee, overuse injuries can also affect the medial and lateral structures. Examples are iliotibial tract syndrome, medial plica syndrome and Breaststroker’s syndrome. While iliotibial tract syndrome causes strain on the tendon of the tensor fascia latae, medial plica syndrome manifests as excessive friction of the medial plica against the condyle of the femur and Breaststroker’s syndrome is manifested as excessive rapid forces loading on the medial collateral ligament. Each of the above-mentioned overuse injuries have a common beginning of rehabilitation, meaning stopping the painful activity in the earliest possible time in order to rest irritated structures. In the later stages, it is important to differentiate these syndromes and to practice strengthening and flexibility exercises in accordance with the diagnosis or otherwise perform adequate surgery. Early detection and treatment is necessary for a better prognosis and prevention of remissions.