Guillain-Barré syndrome is clinically defined as an acute peripheral neuropathy that causes weakness in the extremities, and progresses over a period of several days up to 4 weeks. Epidemiology of the syndrome is about 1.11 cases per 100,000 inhabitants per year, and it is more common in male population. GBS is an autoimmune disease that was previously triggered by a bacterial or virus infection. The syndrome appears in two main forms: as acute inflammatory demyelinating polyneuropathy and in axonal forms as acute motor and motor-sensory axonal neuropathy. The first symptoms are usually pricking or tingling in the feet and hands followed by the appearance of muscle weakness, abnormal sensation, pain, loss of reflexes and autonomic dysfunction. The diagnosis of GBS is based on the patient's history and clinical picture, as well as diagnostic tests. Diagnostic tests include nerve conduction studies, electromyography, and lumbar or spinal puncture. Treatment of GBS requires a multidisciplinary approach. The role of the physiotherapist in the acute phase is focus on patient care and preventive measures. In order to stabilize immune system they use corticosteroids, intravenous immunoglobulin and plasma exchange. In the physiotherapy approach we have physiotherapy assessment and intervention. The physiotherapy assessment means taking medical history followed by objective examination including palpation, observation, measurement procedures and tests. Intervention differs between the acute phase of the disease and the recovery phase. In the acute phase, the main focus is on maintaining lung function, positioning and passive movements. In the recovery phase, at the beginning of rehabilitation, an assessment of strength and functional status is made, followed by exercises in order to return motor functions. Many studies show improvements in various areas of functionality and quality of life after rehabilitation treatments for GBS have been made.