Quadrantectomy is a surgical procedure used in the treatment of early stages of breast cancer. This procedure, also known as a segmentectomy or partial mastectomy, involves removing approximately one-quarter of the breast affected by cancer, along with some of the healthy tissue surrounding the tumor to ensure clean resection margins. Quadrantectomy is considered a gentle operation because it allows the preservation of a larger part of the breast compared to more radical procedures such as mastectomy, where the entire breast is removed. The aim of the study was to examine the postoperative satisfaction of patients after quadrantectomy with regional and general anesthesia. A total of 60 patients were included in the study. The data were collected by contact at the Dubrava Clinical Hospital through a questionnaire created only for the purpose of this research. The data was collected in the period from April to June 2024. The data was collected by the author of the thesis (researcher). The collected data were entered into a Microsoft Excel table. Descriptive statistics were used. The results showed that the median age for patients undergoing general and regional anesthesia is the same and is 60.5 years. The standard deviation for general anesthesia is 11.46 years, while for regional anesthesia it is 11.34 years, indicating similar variability in patient age. The youngest person subjected to general anesthesia is 18 years old, while the youngest person subjected to regional anesthesia is 36 years old. The oldest person subjected to general anesthesia is 88 years old, while the oldest person subjected to regional anesthesia is 85 years old. The age range for general anesthesia is wider than for regional anesthesia, but both types of anesthesia have a similar mean and variability. Both examined groups showed that they were satisfied with the use of both anesthetic techniques in the examined time period. The results of this research can serve as useful guidelines for further research and improvement of practice in breast surgery, with the aim of providing optimal care and improving the quality of life of patients after quadrantectomy.