Melanoma is a malignant tumor of melanocytes, which tends early lymphatic and hematogenous metastasis. The incidence is increasing in many countries of the world, and most often occurs in people with pale skin who are often exposed to the sun. Melanoma occurs in unchanged skin or in percursor lesions . The greatest malignant potential have a large congenital and dysplastic nevi. Melanoma is usually dark in color, from brown to black, but can be with and without pigment. Melanoma passes through three stages of growth: melanoma in situ (means the stage of malignant melanocytes in the basal layer of the epidermis), the radial phase (phase means a lateral expansion) and the vertical phase (phase of the invasion of the dermis). According to clinical and histological features it can distinguish lentigo melanoma (melanoma in situ), LLM (lentigo maligna melanoma), surface-spreading Melanoma SSM (superficial spreading melanoma), nodular melanoma (melanoma nodular NM-) akrolentiginoz melanoma (acral lentiginous melanoma ALM- ). It’s the most common surface spreading melanoma with the highest incidence in the back in men and on the lower limbs in women. Clinical signs suggestive of suspicion of melanoma have an asymmetrical shape, irregular, striated or toothed edges, the color which may vary from light brown to dark brown, size approximately greater than 6 mm. The prognosis of melanoma is associated primary with the tumor thickness (Breslow), presence of ulceration and frequent mitoses. First stage- the primary tumor without metastases has a 5year survival of 75%, the second stage- primary tumor with metastasis to the regional lymph nodes has a survival rates of 25% and third stage- distant metastasis as 0%. Other adverse factors are the regression part of the tumor, microsatellites, older age and male. Treatment is still radical surgery, 1-3 cm in healthy tissue. If the regional lymph node metastases are proven, dissection is performed of the lymph nodes. Early diagnosis and education are the key to successful treatment of malignant melanoma.