Changes happening in human body cells caused by risk factors are called mutations. Consequences od mutations are alterations of genetic code and result of that is abnormal and excessive cell growth. Healthy cells slowly transform into cancerous causing malingnat diseases. Incidence of malignant tumors of head and neck depends on age, sex and risk factors. Malingnant tumors of the head manifest with earache, nose bleed, lymphadenopathy, dysphnoia, stridor and other symphtomes mentioned in elaboration. Presence of one or more symphtomes demands diagnostic workup of the patient. Combining clinical examination, laboratory tests and instumental examinatons helps to make an exact diagnosis. Road to diagnosis is very difficult for patients because it demands complicated workup by several specialists. Form of treatment depends on patients general condition, age and stage of cancer. Basic therapeutic interventions includes surgical procedure, radiotherapy and chemotherapy. Other therapeutic inteventions that a patient can subject to are molecular therapy, hyperthermia, hormonal therapy, genetic therapy, laser therapy and the rest. Treatment process is long-lasting and brings a series of changes that affect the patient and his psychophysical health. With nursing care we make life easier for the patient and his family. Nurse identifies the needs for health care, educate the patient and his family about the disease and adjustments of their lifestyle with malignant illnes. By timely observation nurse can respond adequately to changes of patients condition or problems and then prevent further complications. Regardless of the prognosis of head and neck malignant illnes, patient needs to be rehabilitated and we need to provide him an even better quality of life.