Within this work, a review of the use of biological therapies in the treatment of rheumatoid arthritis is given. Rheumatoid arthritis is a chronic, autoimmune inflammatory disease that affects the several organ systems and significantly damages the quality of life of person. The basic characteristic of this disease is the destruction of cartilage and the formation of bone erosion. The cause of the disease is still unknown. The goals of treatment are to stop further damaging and enable the patient's functional ability. Rheumatoid arthritis is believed to occur in people with genetic predisposition by the action of various infectious and arthritic factors. Non-steroidal anti-rheumatics and analgesics, glucocorticoids and antireumatics that modify the course of the disease are used in classical pharmacological therapy. The most commonly used classical therapy is metrotrexate. It can be used as monotherapy or in combination with the biological drugs. Biological therapy used in the treatment of rheumatoid arthritis includes: TNF-α inhibitors, interleukin-6 inhibitors and drugs directed towards lymphocytes B and T. The role of nurses / technicians in application of biological therapy is very important. Nurses which participate in the application of biological therapy should be educated about the illness, the action of the drug being applied and particularly about possible side effects, so they could respond properly. The nurse also educates patients about biological therapy, exercise directed towards joints relief, advises about daily activities and application of appropriate aids.