Clostridioides difficile was first identefied in 1935. Word „difficile“ is derived from the latin „difficult“, which implies on difficult cultivation. Infections caused by C. difficile add costs to healthcare because of repeated hospitalizations, higher costs, and also represent frustration for the patient. The most common symptom is diarrhea that begins 5-10 days after the start of antibiotic therapy. The main causes of C. difficile are comorbidity and hospitalization. The most important is early diagnosis with the identification of the patient and also starting the therapy which controls the symptoms. C. difficile spores can be found on subjects which come into direct contact with the patient and also on the surfaces around the patient. Metronidazole, vancomycin and fidaxomycin are most commonly used in treatment. Recently, in the literature has been increasingly mentioned fecal transplantation as an alternative. The main goal is to achieve the restoration of the intestinal flora of the diseased person with the aim of transfering the bacteria of the intestinal flora of a healthy donor to the diseased patient. It is important to follow the prescribed guidelines for the treatment of C. difficile infection according to the patients clinical picture. Prevention of the infection with C. difficile in hospitals is very important because of reducing antibiotic consumption. Patient isolation, hand hygiene and enviromental cleanup and disinfection are also important. One of the most effective measures to limit the spread of C. difficile is staff education. It is important for healthcare proffesionals to in form the patient about the spread of C. difficile infection. On the basis of 22 scientific articles, the aim of this study was to investigate and also compare the incidence of C. difficile in different countries and continents, see the rates of diarrhea transmission, recurrence of the disease after the first C. difficile infection and compare the rates of C. difficile infections in different countries and continents. Data for this research were collected by reviewing and comparing published scientific articles in databases ( PubMed, Croatian Journal of Education, Croatian Journal of Infection, Hrčak, Acta Medica Croatica ). The study found that the incidence of C. difficile infections is high. The transfer pathway takes place between patients in the rooms where they are staying, and relapses are often after the first infection of the disease. It has been proven that the rate of C. difficile infections in different countries and continents.