The rapid spread of the COVID-19 pandemic has become a major cause for concern for the entire population and the health profession. Since December 2019, the world is facing an unprecedented infection caused by a new strain of coronavirus called SARS-CoV-2. Challenging urgent, draconian public health measures in many countries around the world has created great uncertainty and unpredictability in which direction will the fight against the new infectious disease go. The battle against COVID-19 infection has not yet been fully clarified. However, what is disastrous with each new outbreak of the disease is social vulnerability. The whole world has witnessed scenes of health system overcrowding due to pandemics, lack of protective equipment, respirators and disinfectants, unpredictable course of the disease, fatal cases and other shocking scenes. A sudden turnaround in the health care system has put health professionals at the forefront of the “fight” against COVID-19 infection. Healthcare professionals on the front lines of defence are exposed to direct contact with confirmed or suspected cases of COVID-19 infection. Constant changes in hospital protocols, reorganization of work, influx of patients, work in intensive conditions and other new challenges of adaptation to the new situation affect both the physical and mental health of health professionals. Seriousness is mostly the mental health of health professionals because it leaves longer and more lasting consequences for both the individual and professional life in the future. Healthcare workers are generally more prone to burnout syndrome due to the very nature of their work, and are particularly at higher risk during a COVID-19 pandemic when job demands are increased and more complex. This thesis examines the attitudes, opinions and impact on the mental health of health professionals on the first line of defence against the COVID-19 pandemic with the use of an anonymous survey. The results of the study indicate that participants experienced poor general conditions such as physical, mental exhaustion, high work pressure and similar things during mobilization due to COVID 19 infection. Greater concern than that they would become ill themselves is that they would transmit the infection to a family member or negative patients. Most of the participants occasionally thought that they could not stand it anymore, they felt “worn out”, they didn't had energy for family and friends in their free time, they were more forgetful and overreacted to common situations. It was the respondents who felt worse who were thinking about quitting. Dissatisfied with the work schedule, less than half of the respondents also believe that they are not sufficiently protected in working with suspected or positive patients with COVID-19 precisely because of the department in which they currently work and the health profession. Therefore, it is important to invest in human resources in health care in the form of education and in the protection of mental health of employees by the system in order to be ready at all times to provide patients with the most adequate care.