The name schizophrenia comes from a combination of the Greek words shizeiu - to split and fren - reason. Eugen Bleuler has introduced the name schizophrenia in 1991 and the goal was to replace the negative meaning of the disease. Schizophrenia is a mental illness that does not allow a sick person to distinguish the real from the unreal experience, interferes with daily thinking and emotional experiences towards others and disrupts normal social functioning. The symptoms that occur in this disease are delusions, hallucinations, illusions, disorganization and impoverishment of mental functions. The symptoms of the disease are divided into positive and negative. The disease occurs between the ages of 15 and 35, and we recognize it by its early symptoms, sometimes these symptoms are absent, so the disease is noticed only in the acute phase, only the beginning of the disease is gradual or sudden. The diagnosis of schizophrenia requires that the patient's symptoms be present for at least six months and that there is a prodromal phase that lasts for another 5 months, with some symptoms maintaining, but in a milder form. Schizophrenia is treated with drugs, but they are not enough to achieve the highest possible level of independence in patients later in life, so psychosocial methods are also used. It is of great importance to involve the patient's family, environment and community in the treatment process so that the return to normal life and recovery is as fast and high quality as possible. Schizophrenia is the most stigmatized mental illness, it is caused by prejudice, stigmatization entails discrimination, which ultimately has negative consequences for the patient and his family. A nurse is the person who spends the most time with a patient with schizophrenia, so she is the only one who can notice problems in the field of health care. Nursing documentation is also of great importance and the first step in patient care. To solve the problem, the nurse selects the most appropriate nursing interventions that are patient-centered and individualized for himself. A good and quality relationship of trust between the nurse and the patient is the most important characteristic of quality health care.