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undergraduate thesis
Citopatohistološka korelacija analize uzoraka vrata maternice
2021. urn:nbn:hr:122:351847
Borovčak, Nikolina
University North
University centre Varaždin
Department of Nursing

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Borovčak, N. (2021). Citopatohistološka korelacija analize uzoraka vrata maternice (Undergraduate thesis). Koprivnica: University North. Retrieved from https://urn.nsk.hr/urn:nbn:hr:122:351847

Borovčak, Nikolina. "Citopatohistološka korelacija analize uzoraka vrata maternice." Undergraduate thesis, University North, 2021. https://urn.nsk.hr/urn:nbn:hr:122:351847

Borovčak, Nikolina. "Citopatohistološka korelacija analize uzoraka vrata maternice." Undergraduate thesis, University North, 2021. https://urn.nsk.hr/urn:nbn:hr:122:351847

Borovčak, N. (2021). 'Citopatohistološka korelacija analize uzoraka vrata maternice', Undergraduate thesis, University North, accessed 07 April 2025, https://urn.nsk.hr/urn:nbn:hr:122:351847

Borovčak N. Citopatohistološka korelacija analize uzoraka vrata maternice [Undergraduate thesis]. Koprivnica: University North; 2021 [cited 2025 April 07] Available at: https://urn.nsk.hr/urn:nbn:hr:122:351847

N. Borovčak, "Citopatohistološka korelacija analize uzoraka vrata maternice", Undergraduate thesis, University North, Koprivnica, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:122:351847

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Metadata
TitleCitopatohistološka korelacija analize uzoraka vrata maternice
Title (english)Cyto-pathohistological correlation of cervical specimens´ analysis
AuthorNikolina Borovčak
MentorBiserka Pigac (mentor)
Committee memberHrvoje Hećimović (predsjednik povjerenstva)
Committee memberBiserka Pigac (član povjerenstva)
Committee memberIvana Živoder (član povjerenstva)
GranterUniversity North
(University centre Varaždin)
(Department of Nursing)
Koprivnica
Defense date and country2021-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Karcinom vrata maternice četvrti je po učestalosti i smrtnosti od karcinoma u žena, a 70 % ih se javlja u razvijenim zemljama. U brojnim istraživanjima humani papiloma virus (HPV) dokazan je kao glavni uzročnik malignih promjena vrata maternice. Cervikalna citologija (PAPA test) najbolji je morfološki test probira za rak koji pomoću analize brisa vrata maternice otkriva predstadije i rane stadije raka vrata maternice. Njegova upotreba dovela je do velikog smanjenja morbiditeta i mortaliteta od... More raka vrata maternice. Iako je tako, u nekoliko istraživanja proučavana je učinkovitost PAPA testa u kojima je zaključeno da se gotovo u 30 – 40 % slučajeva nalazi nepodudarnost abnormalnog PAPA testa s odgovarajućim patohistološkim nalazom. Biopsijom, kojom se dobiva tkivo, patolog je taj koji se jedini može definitivno izjasniti o prirodi promjene na vratu maternice. Prema tome patohistološka dijagnoza smatra se zlatnim standardom u dijagnostici preinvazivnih promjena vrata maternice. Patohistološki, u 75 – 85 % bolesnica riječ je o karcinomu pločastih stanica, a ostalih 15 – 25 % odnosi se na adenokarcinom vrata maternice. Cilj istraživanja je ispitati podudarnost PAPA nalaza s pripadajućim patohistološkim nalazom uzorka vrata maternice (citopatohistološka korelacija). Istraživanje je provedeno u Općoj bolnici Varaždin na Odjelu za patologiju, sudsku medicinu i citologiju u razdoblju od 2015. do 2021. godine. Rezultati pokazuju da je citopatohistološka korelacija nađena u 6 (20 %) od ukupno 30 slučajeva dok je u 24 (80 %) slučaja bilo nepodudaranja citološkog sa patohistološkim nalazom. Od ukupno 30 pozitivnih citoloških nalaza, patohistološki je u samo 16 (53,3 %) slučajeva potvrđena preinvazivna promjena vrata maternice. U 4 (13,3 %) slučaja o stupnju displazije nije se moguće izjasniti zbog neadekvatnog uzorka. Istraživanjem se otkrila korelacija između citoloških i pripadajućih patohistoloških nalaza uzoraka vrata maternice tek u 20 % slučajeva dok se u 80 % slučajeva nalazi ne podudaraju. Less
Abstract (english)
Cervical cancer is the fourth most common cancer in women; with the incidence of 70 % in developed countries. Many studies have proved that human papillomavirus (HPV) is the main cause of cervix malignancy. Cervical cytology (Pap smear) is the best morphological screening test used for early diagnosis of pre – stages and early stages of cervical cancer. This method usage has led to lower rate of cervical cancer morbidity and mortality. However, results of a few studies have shown that there... More is a mismatch in 30 % – 40 % cases of abnormal Pap smear test results and patho – histology test results. After undergoing biopsy, the tissue is analysed, than a pathologist defines the nature of the pathological changes of cervix. Therefore, patho – histological diagnosis is considered to be “the golden standard” for invasive changes of cervix. According to patho – histological results, squamous cells cancer occurs in 75 % – 85 % cases; while adenocarcinoma occurs in 15 % – 25 % cases. The aim of this paper is to study correlation between Pap smear test result and corresponding patho – histological results in the case of cervix cancer (cytopathological correlation). The study has been taken in General hospital Varaždin, at the Department for Pathology, Forensic Medicine and Cytology between the year 2015 and 2021. The results show that there is cyto – patohystological correlation in six (20 %) cases out of thirty recorded cases; while in twenty – four (80 %) cases there was no correlation of cytological and patho – cytological diagnosis. Out of thirty positive cytolo gical test results, in only sixteen (53,3 %) cases there was verified pre – invasive patho – histological finding of cervix changes. In four (13,3 %) cases, the final diagnosis of dysplasia degree couldn’t be set due to inadequate specimen. The study shows that there is correlation between cytological and corresponding patho – histological test results in only 20 % cases, while in 80 % cases the test results do not correlate. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:122:351847
Study programmeTitle: Nursing
Study programme type: professional
Study level: undergraduate
Academic / professional title: stručni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) sestrinstva (stručni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) sestrinstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-22 14:11:00
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