CNS (central nervous system) tumors represent intracranial neoplasms within the cerebral parenchyma or central spinal canal and/or other cns structures (meninges, cranial nerves). Malignant brain tumors can be categorized into two groups: primary malignant tumors that have formed within the brain and secondary tumors resulting from primary tumors in other organs. The most heterogeneous and also the largest group of primary cnsic tumors are neuroectodermal tumors. Central nervous system gliomas are the most common primary brain tumors, accounting for 81% of CNS malignancies. They are formed from glial or precocious cells. The WHO (World Health Organization) classification refers to the categorization of gliomas into four degrees of tumor differentiation, which can be well or poorly differentiated. Glial tumors are infiltrative tumors that differ in the expansion of the zone of infiltration and have the ability to make malignant transformation. Glioblastoma (Glioblastoma multiforme, GBM) is the most malignant form of astrocytoma, characterized by aggressive and invasive growth. Major challenges in the treatment of GBM are its genetic heterogeneity and infiltrative nature. The clinical picture consists of general symptoms that arise as a result of an increase in intracranial pressure and local symptoms that arise as a result of the localization of the tumor. When suspecting a CNS tumor, it is necessary to do a neurological examination, take anamnesis and heteroanamnesis, pay attention to the symptoms. It is necessary to do an EEG and an oculist examination. The most significant methods for proving tumors are neuroradiological methods that include magnetic resonance imaging (MRI) and computed tomography (CT). To make an accurate diagnosis of the tumor, a biopsy and histopathological analysis are used. A tumor biopsy can be done during surgery to resection the tumor. If the tumor is located in a hard-to-reach place, a stereotactic biopsy is performed. Radiotherapy is considered the standard for the adjuvant approach to treating glioblastoma, but it is also used in inoperable tumors. Cytostatics have been adjuvantly used for years in the primary treatment of malignant gliomas. Perioperative care is based on the concept of integrated and multidisciplinary care for the patient from the moment the neurosurgeon sets the indication for surgery until the patient's full recovery. Perioperative care includes preoperative, intraoperative and postoperative care. In preoperative care, the emphasis is placed on the psychological and physical preparation of patients for surgery. While postoperative care is focused on monitoring the patient's condition with the aim of eliminating and reducing physical symptoms and detecting and preventing post-operational complications. In all three phases of perioperative care, the nurse has a significant role in the care of the patient because she is the one who spends the most time and care for him along with the patient.