Medical dispatchers play a key role in emergency medical situations, especially when it comes to cardiopulmonary resuscitation. Their ability to give instructions quickly and accurately can mean the difference between life and death. However, the responsibility that comes with this role can be a source of significant stress. Medical dispatchers face great challenges and stress when giving instructions for cardiopulmonary resuscitation. Knowing that their instructions and quick assessment of the situation can directly affect the outcome of resuscitation is a huge burden. Fear of possible mistakes and their consequences further contributes to stress. The urgency of the situation, emotional burden, responsibility for outcomes and lack of visual contact are just some of the factors that contribute to their stress. The aim of this research was to analyze the experiences of medical dispatchers when giving instructions for cardiopulmonary resuscitation, with a special focus on the stress they experience during this aspect of the job, using a qualitative approach. Qualitative methodology enables in-depth insight into the attitudes and feelings of respondents, and the research was conducted through semi-structured interviews, with an emphasis on phenomenological analysis. The consequences of stress can be serious, including physical and psychological problems and reduced work efficiency. Stress can negatively affect concentration, reaction speed and decision-making ability. This can lead to an increased number of mistakes, which further increases stress and creates a vicious cycle. However, there are a number of stress management strategies that can help dispatchers deal with these challenges. Education, workplace support, relaxation techniques, clear procedures and a positive work atmosphere are key elements in reducing stress and improving the general well-being of medical dispatchers. Qualitative analysis shows that the professional experience of medical dispatchers significantly depends on the quality of interaction with callers. Although the age of the person being instructed in CPR cannot be influenced, three key aspects—interaction with the caller, education of the caller, and panic management—can be improved through public health education campaigns. Dispatchers have confidence in their competence, which helps them to cope with challenges, but they emphasize the importance of continuous education on concentration and communication techniques. Education can improve their skills and ensure professionalism. However, communication is more difficult with less educated callers, which increases stress. Therefore, it is important to improve working conditions, provide psychological support and encourage public discussion about the challenges of dispatchers in order to improve their well-being and work efficiency. The stress associated with giving CPR instructions is complex and can seriously affect the dispatcher's efficiency and health. Understanding the causes of stress and applying strategies to manage it is critical to maintaining the professional effectiveness and well-being of dispatchers. Providing support, improving working conditions and training are key measures to reduce stress and improve their ability to provide help in emergency situations. Through systematic and continuous training, it is possible to create a working environment in which dispatchers will be able to perform their work efficiently and at the same time maintain their health and well-being. This paper will investigate the stress level of medical dispatchers when giving instructions for cardiopulmonary resuscitation.