Introduction and goal: Hemodialysis is a procedure that removes excess fluid and metabolic waste products from the blood of patients, returning purified blood to the patient's body. There are three different vascular accesses for hemodialysis, which include arteriovenous fistula, graft, and central venous catheter. In addition to creating the vascular system, the treatment of hemodialysis involves changes in food and fluid intake, the occurrence of possible complications related to the treatment, changes in family and work status, and adapting to life with hemodialysis treatment. Significant changes associated with hemodialysis treatment can cause various psychological and physical stressors and may impact the quality of life. The aim of this research is to determine which stressors affect the lives of hemodialysis patients and to what extent, as well as their satisfaction with their quality of life. Methods: The research was conducted at the County Hospital Čakovec. A total of 58 out of 74 patients on the chronic hemodialysis program participated in the study. A survey questionnaire was created and given to the patients to fill out using the pencil-and-paper method. Results: The study showed that patients, on average, indicated that they rarely experience stress related to the examined stress factors. The highest levels of stress were reported as being caused by feelings of fatigue, thirst, and maintaining an ideal body weight, while the lowest levels of stress were reported for equipment failure during hemodialysis and frequent needle sticks due to vascular access. The portion of the study related to satisfaction with quality of life showed that patients are generally satisfied with their quality of life and that satisfaction does not depend on the age of the respondents. Conclusion: The challenges of stress and satisfaction with quality of life reflect the quality of healthcare and the education provided by the healthcare team. Each individual reacts differently to stressors. The nurse or technician is the first person the patient meets when entering the hemodialysis unit and is present with the patient throughout the entire treatment process. By identifying stressors and assessing the quality of life of patients, nurses and technicians can significantly improve treatment outcomes and the quality of healthcare. This knowledge enables better adaptation of care to the needs of patients, leading to greater satisfaction for patients undergoing chronic hemodialysis.