Crohn's disease is a chronic inflammatory disease that can affect any part of the gastrointestinal tract, but most commonly the small intestine, i.e. the terminal ileum, less frequently the colon. Many compare the Crohn's disease to the ulcerative colitis. Both are inflammatory bowel diseases, however the difference is that in ulcerative colitis pathological changes primarily affect the mucous membrane while in Crohn's disease the mucosa and submucosa are affected, and it penetrates into the deeper layers of the wall. The course of the disease is highly variable, with many remissions and relapses, the various manifestations of the disease, frequent perianal, intestinal, extraintestinal complications, and frequent recurrence after surgical resection of the diseased segment of intestine. The cause of Crohn's disease is unknown, but is suspected to contribute to hereditary characteristics. Although considered long-term and chronic, treatment for Crohn’s disease can be kept under control and long periods without symptoms can be achieved. Many patients lead a quality and fulfilled life regardless of the symptoms and the disease. The role of nurses in the care of chronically ill people are very broad scale, starting primarily from the appropriate communication skills, to the more complex process of nursing care for such patients. It requires a lot of knowledge, patience and empathy to work with such patients.The creation of a therapeutic relationship, socioemotional climate, and therapeutic communication between nurses and patients are important prerequisites for achieving the goals of nursing in the care of chronically ill patients whose underlying disease is often accompanied by psychological changes, which further complicate the underlying disease.