Polytrauma is a serious injury to two or more body regions where at least one injury or combination of several of them endangers life. Polytrauma encompasses all serious, life-threatening injuries, and most commonly occur in traffic accidents and falls from height. Time is precious in taking care of a polytraumatized patient and in his care we use the concept of "the golden hour" to practice the beginning of the treatment of traumatic injury within 60 minutes of its occurrence. When taking care of the polytraumatized patient, we find two aspects of hospitalization: prehospital and hospital. The prehospital part of the patient's care begins at the place of an accident, and the primary goal is survival of the patient with normal cognitive functions. In a clinical approach to treatment, we use care algorithms, with the help of which we strive in the timely and accurate sequence of diagnostic and therapeutic procedures to achieve better results while minimizing the failure to the lowest possible level. The hospital part of the polytraumatised treatment begins with the transport of the patient to the nearest appropriate institution for further treatment. Working with severe patients, such as polytraumatized patients, requires higher education of medical technicians/nurses, continuous education, high-quality skills, and preparedness to react quickly and in a certain way in certain situations. For this reason, it is necessary to encourage all members of the health care team to take care for such patients for a permanent renewal of knowledge, for the purpose of progress, quality care and mortality reduction.