Urogenital infections are one of the most common inflammatory diseases that affect society as a whole and endanger the patient in his daily activities and work. Urethritis or inflammation of the urethra represents a sexually transmitted infection. Women have an increased risk of developing urethritis and urinary tract infections than men, which is a consequence of female anatomy. More specifically, the urethra is shorter in women, making it easier for microorganisms to enter and cause infection. Most notable symptoms of urethritis are dysuria, urethral discharge, frequent urination, discomfort and pain in the urethra. Urethritis is etiologically categorized as gonococcal, if the causative agent is Neisseria gonorrhoeae, or as non-gonococcal, which are caused by Chlamydia trachomatis, Mycoplasma genitalium, Ureaplasma urealyticum and Trichomonas vaginalis. In addition to infectious causes, there are types that occur as a result of chemical, mechanical and non-infectious causes. Urethritis, like other sexually transmitted diseases, represents a major public health problem. The development of urethritis is further aided by poor hygiene habits, impaired immunity, as well as unprotected sex. Chronic urethritis often leads to the stricture of the urethra (narrowing of the urethra), and epididymitis and prostatitis can also occur. Antibiotics are the main treatment for urethritis, while the dosage and drug selection is guided by the physician. Reproductive health prevention should not only focus on acquiring knowledge and preventing sexually transmitted diseases and unwanted pregnancy, but on changing attitudes and adopting responsible sexual behaviour. The role of highly educated nurse is to provide the patient with the best care possible and to refer him or her for further treatment. The aim of this paper is to describe urethritis, aetiology, diagnosis, treatment and prevention of urethritis.