Transplantation is an organ or tissue replacement procedure when the function is so reduced that it endangers life and its quality, and all other treatments have already been used. The first successful transplant was performed about 30 years ago. By explantation, the donor organ or tissue is removed and transplanted to a person who will get an opportunity for quality of life through transplantation. Explantation is today the highest level in the treatment of patients whose life is limited and who can expect death. Prior to transplantation, explantation is required. The basic procedure is detection of a potential donor that needs to be found after which there is a procedure where brain death is mandatorily determined, which is required by the prescribed law. Brain death is proven by performing clinical tests in which the reflex of the brain stem is missing, and by a paraclinical test that proves the cessation of brain activity. With the consent of the family, the explantation process of the donor starts. It is essential to maintain an adequate organ perfusion. In this complex procedure with the entire hospital team one of the main links is the presence of the nurse. The nurse is very important in the transplant process, she prepares the patient, gives him psychic support, educates him about the procedure and physically prepares the patient for the procedure. In addition, the nurse assists the surgeon in transplantation, nurtures the patient after the transplant procedure and assists her expertise so that the body does not reject the transplanted organ.