Total mastectomy is a surgical procedure that removes one or both breasts, and which impairs the quality of life of sick people and has consequences such as problems with their own body image, problems in the family, business and social life. It is indicated by the occurrence of breast cancer, and the statistics on its frequency are devastating and have long been a challenge to medical staff and other professionals who have been trying for years to find a way to reduce mortality and severe consequences. For women, the breast is a symbol of fertility, femininity and life, so the diagnosis of breast cancer itself is a great fear. Patients need attention and understanding and the creation of a sense of security on the part of the family and medical staff in order for the patient to feel better mentally and physically, especially those who have undergone complete breast loss. The aim of this study was to investigate the information and attitudes of the general population about mastectomy as a preventive measure and one of the ways to treat breast cancer, depending on sociodemographic data, medical or non-medical orientation and knowledge of the patient. 611 participants from the general population participated, and a quantitative research approach was used and a cross-sectional study was conducted. To obtain data in the research, a survey questionnaire was used, which was independently developed for the purposes of conducting the research. Only participation in the questionnaire was voluntary and anonymous. The obtained results testify that the vast majority of participants know a person suffering from breast cancer and are familiar with the concept of mastectomy. It can be concluded that the general population is relatively well informed, but there is still too little talk in society about total mastectomy. An important role is played by the nurse who is part of the medical team and whose knowledge and skills influence the informing of the general population and the well-being of patients undergoing total mastectomy.