The cervical spine is a complex part of the body in which the vital components of the human body are located. The high sensitivity of such a part of the body requires precision in diagnosis, but also in the way of treating pathology caused by certain causes. One of the common musculoskeletal diseases is cervicobrachial syndrome. CS is nowadays a common degenerative and neurological disorder whose causes are musculoskeletal diseases and degenerative changes. Diagnosis of pathophysiological mechanisms is based on tests such as magnetic resonance imaging, electromyoneurography and radiography. Provocative tests are also used to examine certain mechanisms of pain. While the diagnosis of pain is based on the anamnesis, ie clinical examination. The symptoms present as pain in the neck area that irritates towards the hands. Such pain and other symptoms lasting more than 12 weeks are considered chronic. Physical therapy is the primary element in the treatment of chronic pain. In addition to physical therapy, pharmacological therapy is at the forefront of the treatment of chronic pain. Psychological and psychiatric factors greatly influence chronic pain. They can cause disorders such as anxiety, depression, social phobia, etc. Treatment must therefore be based on a multimodal approach that requires the involvement of different medical branches. The elements that such an approach encompasses are physical therapy, cognitive-behavioral therapy, pharmacotherapy, invasive and minimally invasive procedures, and complementary methods of treating pain.