Amyotrophic lateral sclerosis, also known as motor neuron disease and Lou Gehring's disease, is a fatal neurodegenerative disease. It is also one of the most enigmatic diseases of today's medicine precisely because of the lack of information about its pathogenesis and origin. Along with Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis is one of the most common neurodegenerative diseases. It belongs to the group of progressive diseases that include degeneration of the motor system at all levels. The clinical features of amyotrophic lateral sclerosis are the loss of neurons at all levels of the motor system - from the cerebral cortex to the anterior horns of the spinal cord. Loss of lower motor neurons that extend from the spinal cord to the muscles leads to muscle weakness, fasciculations, cramps, irreversible loss of body mass - loss of fat and muscle tissue. Features of lower motor neuron loss contribute to mortality more than features caused by upper motor neuron loss, which include spasticity, clumsiness, and functional impairment. Due to the relatively rapid progression of the disease, which leads to severe disability, patients have a very short life expectancy after diagnosis. In the treatment of people suffering from this disease, a multidisciplinary approach and the cooperation of the entire healthcare team are needed. Physiotherapy approach to patients consists of subjective and objective individual assessment, development of a plan and physiotherapy interventions. The basic goals of physiotherapy are aimed at improving function, increasing the patient's independence and quality of life. In the terminal phase of ALS, the goal is to relieve symptoms and maintain the best possible quality of remaining life. The primary goal of physiotherapy is to maintain the patient's independence and functioning in activities of daily life. Secondary goals are the evaluation of the patient's needs and medical interventions, the education of the patient and family, the application of the necessary therapeutic procedures and the prevention or mitigation of the consequences of incapacitation. The emphasis is on movement therapy, respiratory therapy, hydrotherapy and manual therapy.