Multiple sclerosis is a chronic autoimmune disease of the central nervous system that causes inflammation and demyelination of nerve fibers. Inflammatory damage can affect the cerebrum and cerebellum, brainstem and spinal cord. Today's findings indicate that it is caused by the interaction of several factors that are partly genetic and partly environmental. The way the disease will manifest itself depends on the place where the damage occurred. The basic feature of the disease is the formation of demyelinated plaques in places in the brain or in the spinal cord where the sheath has been damaged, and often the optic nerve is also affected. The consequence of damage to the nerve sheath is the blockage of nerve impulse transmission between nerve cells, and thus the disruption of various functions in the central nervous system. It can occur at any age, but is most common between the ages of 20 and 50. Women are affected more often than men. In most cases, the first symptom of multiple sclerosis is a relapse caused by inflammation of the central nervous system. Symptoms can appear suddenly or gradually and vary in intensity and duration. The disease was first described by Jean Martin Charcot in 1868, defining a diagnostic triad that includes the dissemination of lesions in space and time. In terms of treatment, there is a difference between treatment during the worsening of the disease or treatment with long-term treatments of the present symptoms. Physiotherapy is one of the important methods of treatment. The basic goal of the physiotherapy approach is aimed at preserving and improving the functional abilities of patients with the aim of improving the quality of life and independence in daily activities, taking into account the stage of the disease and the symptoms present.