Spina bifida is a congenital defect caused by improper or incomplete closure of the neural tube. It comes in two forms, which are closed (occulta) and open (cystica). The open type is divided into meningocele and myelomeningocele, which is considered to be the most severe congenital malformation compatible with life. The exact cause is still unknown, but it is known that a deficiency or problems with the absorption of folic acid can cause difficulties associated with the closure of the neural tube. Because of this, as a method of prevention, many countries have determined the minimum dose of folate that must be found in food. As for diagnostics, this condition is diagnosed prenatally and most often indirectly, by observing abnormal proportions of the bones of the skull. The treatment is complicated and requires surgery to close the spina bifida. With the development of knowledge in medicine, these interventions began to be performed while the fetus is still in the womb, and in this way, it is given greater chances for independent recovery until delivery. A child born with this deformity in most cases suffers from hydrocephalus and Arnold Chiari malformation, most often type II. Some other conditions that often accompany this diagnosis are problems with the urinary and digestive systems, problems with the musculoskeletal system, cognitive difficulties, latex allergy and many other conditions that depend on the severity of the deformity itself. Since spina bifida has a great impact on the locomotor system, affected children require extensive physiotherapy. It includes a thorough assessment in which all structures on the body, posture, surgical scar, movement in space and many other components are observed. Goals and a therapy plan are then set, followed by physiotherapy intervention that can last for years. It most often includes certain concepts such as the Boobath technique, Vojta, Baby Handling and water exercises. In order for the outcome to be as good as possible, it is necessary to involve a multidisciplinary team and the child's parents, who are also the main ones in habilitation because they are with him 24 hours a day. The case report shows a 19-month-old boy with myelomeningocele who comes to neurodevelopmental physical therapy and where efforts are being made to bring his severe condition to the level where the child will one day be at least partially independent.