Among the leading public health problems in Croatia, Europe and other areas of the world, is the drug abuse which as a medical, as well as a social phenomenon causes general attention for many years. Taking care of adolescents is on all of us. Often we look for causes in families, schools, the police, society or modern times. Only together, with the power of team work, we can be efficient and effective in accomplishing our mission which is prevention of addictive behaviour. Prevention of addictive behaviour includes different aspects of activities which are primarily related to youth due to their sensitivity and tendency for starting with addictions. The most important prevention measures are being implemented by the Croatian Government, schools, the health system and nurses. Croatian Government is conducting researches and keeping registers based on which they receive valuable information and make conclusions about number of addictions, in which age group and gender they usually occur, which are the most common addictions etcetera. Based on these facts they get necessary information on which they can make plans and strategies for prevention of addictions. School, based on Governments guidelines, laws, annual plan and programs implements the prevention of addictions. One of the most important role in the prevention of addiction has family. Family is the one which will provide a healthy environment, proper internal communication and sense of security to an adolescent. Family members are the ones who first notice changes in behaviour and way of thinking of adolescents, so they have to provide them an example of healthy and fulfilled life with purpose to build a meaningful future.