This paper discusses the issues concerning the relationship between communication and culture, i.e. the relationships between business people coming from different cultures. Globalization has created a need of business people for an increasing cultural awareness, the acceptance of cultural specificities and the manner in which business is done in different parts of the world. In order to avoid any possible embarrassment, a businessperson has to be familiar with the customs, rules, good manners and values of his/her business partners from other countries. The paper exposes the idea of cultural intelligence, i.e. how cultural intelligence influences the interaction between different cultures. The emphasis is given to the importance of nonverbal communication in human interaction. The manners of a more successful and more harmonized communication while doing business with people from different countries are discussed, as well as what skills are important for intercultural communication. The research shows the results regarding the attitudes of the respondents towards other cultures, the need to speak foreign languages, the cooperativeness of business partners of different cultural background, the efficiency of the application of intercultural patterns in business communication, the presence of prejudice and stereotypes in respondents towards individuals of different cultural characteristics.