Taking medication on your own initiative is an integral part of self-help that a person applies whenever he finds himself in a situation of impaired health. Various studies confirm that out of thousand people, three-quarters of them have a health problem within a month, but treat it on their own initiative. According to the position of the World Health Organization, self-treatment should be encouraged, partly because of better awareness of one's own health, partly because of the relif of the health system and financial savings. However, considering that these are substances that could hvae unwanted side effects if not used according to the instructions, a cautious approach to self-medication is required. This research will present the general knowledge, attitudes and experiences of nursing students about over-the-counter drugs. The target group are nursing students in the Republic of Croatia, among whom some are just at the beginning of their studies and without work experience and some already have many years of work experience in various fields of the profession. The research was conducted through an online anonymous questionnaire, fowarded to the groups of students from different universities and polytechnics in the Republic of Croatia. The survey showed an insight into the respondent’s age, work status, general knowledge and attitudes about over-the-counter drugs and their own experience with the use of over-the-counter drugs.