Interstitial cystitis is a chronic non-infectious bladder disease, which is mainly manifested by pain in the pelvis and suprapubic area, with frequent urination accompanied by constant urgency and nurture. Depending on the cystoscopic finding, it is divided into an ulcerative and nonulcerative type. It is important to point out that the symptoms of interstitial cystitis resemble symptoms of cystitis only in this case there is no bacteria in the urine. The strength of the symptoms mentioned varies, and is relatively worse with age because of the damage to the urinary bladder wall. Recent epidemiological studies show a prevalence of about 50 to 70 people with 100,000, more often affects women, the average age of about 40 years, and has a long-lasting impact on changing the quality of life. Symptoms of interstitial cystitis often vary, occasionally spontaneously regress over time, but they also intensify with some food, stress, anxiety, depression or menstrual circle. The aim of this work is to describe interstitial cystitis, the causes of the disease, clinical picture, frequency of deterioration, and methods and methods of treatment. Since the disease is chronic and incurable, the role of a nurse will be significant in care for a patient with interstitial cystitis. Therefore, the importance of her role and the specificity of her approach to the patient is stated. Interstitial cystitis is a serious problem for the physician and patient due to unclear etiology, long and exhaustive treatment and poor response to therapy.