Nowadays there is an increasing presence and use of antibiotics in the treatment. Antibiotics are prescribed daily to at hospital level, and local by general practitioners. Consequently an increased presence of antibiotics can lead to the excessive antibiotic treatment that results in the problems of resistance, or resistance of bacteria and bacterial infections to antibiotic drugs. With the patients in turn leads to the fact that a significant number of patients careless approach to treatment with antibiotics is not following the instructions of treatment, disregarding the time limit treatment, wrong care or saving antibiotics for the purpose of later self-healing, etc. Education of antimicrobial therapy by the medical team is a very important step for reducing unnecessary and undisciplined consumption of antibiotics. Although we live in a time when our health information available at any time, either through the media and the Internet, either through books, magazines, scientific articles, a large number of patients believe that antibiotics work on viruses, but not to a bacterial infection. Given the situation and the problem of antibiotic treatment in the health survey was conducted which was aimed to examine the knowledge and attitudes of the general population on antibiotics and see the views and opinions of the respondents on the importance of the proper implementation of oral antibiotics in order to obtain a clearer picture of the actual problems. In a study involving participants of all ages, different grade levels, subjects with and without the medical profession in order to obtain the results of a wide range of opinions. The survey was conducted on-line survey on social networks through Google form over a period of 20.6.2018.- 20.8.2018. The survey is divided into two parts. In the first part were collected general information about the subject, and the second part consisted of 15 questions on general knowledge and the use of antibiotic drugs. The study was conducted on the sample of 181.