Until recently, celiac disease was considered a rare disease in white children and was primarily characterized by gastrointestinal problems. Today's knowledge is different, so today it is considered a common, autoimmune disease, which can occur in all of peoples age, racial and ethnic groups. Thus, celiac disease is one of the most common chronic gastroenterological, childhood, and systemic diseases. The classification of celiac disease can be viewed from several aspects, as a classic form of the disease, then as an atypical disease, asymptomatic (silent) disease and as a latent disease. It should be noted that there is a whole range of different symptoms of this disease. Thus, some of the symptoms of childhood celiac disease are as follows: chronic diarrhea, vomiting, increased abdominal volume, weight loss, fatigue, flabby muscles, etc., while symptoms in adulthood include the following: weight loss, diarrhea, anorexia, nausea, vomiting, anxiety , depression and a range of other general, gastrointestinal, metabolic and endocrine, musculoskeletal, neurological / psychiatric and reproductive and skin symptoms. Regarding the diagnosis of celiac disease, after identifying the patient in whom this disease is suspected, it is necessary to conduct initial testing in those patients who use gluten-free foods in their daily diet. Initial testing is performed by serological methods. Early diagnosis can prevent complications of this disease, and the only therapy is a gluten-free diet.