The COVID-19 pandemic is considered the most important global health disaster of the century and the greatest challenge humanity has faced since World War II. In December 2019, a new contagious respiratory disease appeared in Wuhan, Hubei Province in China. A new class of coronavirus, known as SARS-CoV-2, is responsible for the onset of this disease. According to a report by the World Health Organization (WHO of April 18, 2020), the current COVID-19 epidemic has affected more than 2164111 people and killed more than 146.198 people in more than 200 countries around the world. In January 2022, the EMA recommended that Paxlovid be granted conditional approval for the treatment of COVID-19 for all EU members. Almost all countries are struggling to slow disease transmission by testing and treating patients, quarantining suspects by monitoring contacts, restricting large gatherings, maintaining full or partial closure, etc. This paper describes the impact of COVID-19 on society and the global environment and has also discussed possible ways in which the disease can be controlled. The purpose of the research was to examine the knowledge, attitudes and opinions of the population in the Republic of Croatia about Covid-19 disease and vaccination against Covid-19. Whether they were vaccinated arbitrarily, whether vaccination should be mandatory, and what their previous experiences with diseases caused by the Covid-19 virus should be examined. The survey was conducted in September 2021. The study involved 627 participants voluntarily, of whom 521 were women and 106 were men. The age group of participants was between 15 and 80 and older, but the most common age was between 21 and 40 years. An online survey was used for the survey. An online survey was created using the Google Docs web application and posted on the social network Facebook. The survey contained 42 questions with offered answers or the possibility to offer them yourself. The instructions explain the purpose and goal of the research and emphasize that the research is completely anonymous and that the results will be used exclusively for the purpose of preparing the final paper. The hypotheses were confirmed, but we can see that the trend of non-vaccination through certain issues is becoming increasingly popular (51.1%). Through some questions we can see how respondents are concerned and unsure about the effectiveness and safety of vaccines (36.8%), and do not have a defined position on vaccination and vaccines (32.9%). By conducting such research, we can see the attitudes and opinions of the population, what worries them the most and in which direction to educate them.