Methicillin-resistant Staphylococcus aureus (MRSA) infections remain a major global public health problem. Of concern to us is S. aureus bacteremia, which has high morbidity and mortality and can lead to metastatic or complex infections such as infective endocarditis and sepsis. MRSA is responsible for most cases of S. aureus bacteremia in humans worldwide, compared to methicillin-susceptible S. aureus. In the case of S. aureus, MRSA infection is associated with poor clinical outcomes. The combination of the lack of resistance and susceptibility to first-line antibiotics and the lack of equally effective alternatives complicates the treatment of MRSA bacteremia. The aim of this work was to determine the frequency of MRSA among hospital patients. The aforementioned data were processed using descriptive and analytical statistical methods in order to show the prevalence of infection, the distribution of cases by Department, and possible differences depending on age, gender, and comorbidities present. The results of the research showed that during 2021 MRSA infection was widespread in several departments of OB Varaždin, Service for extended treatment and palliative care Novi Marof, but that the number of patients in these departments was almost equal, age differences were noted among the patients, gender differences and the presence of various comorbidities. The results of the study revealed that the patients died from the underlying disease or its sequelae, not from problems related to MRSA. MRSA is still a major health problem. MRSA bacteremia is difficult to treat, especially in patients who are at high risk of complications or have toxigenic or multidrug-resistant strains. Early detection of MRSA is essential for timely implementation of appropriate treatment. There is an urgent need to improve effective MRSA treatments and implement infection control procedures. The tasks of a master's nurse is one of the most important elements in the suppression and implementation of infection prevention measures, which requires team synergy and adherence to the given protocol of the health institution. When the disease occurs, it is important to identify risk factors and take all necessary measures to limit the spread of infection, especially in hospital settings. Everything is built on hand hygiene.