Skin pigment changes represent one of the most important areas in dermatological oncology, as it is sometimes difficult to distinguish between a benign nevus and a malignant melanoma. Nevi are categorized into congenital and acquired based on the time of onset. Factors such as light skin, light eyes, and blond hair color can also influence the number and development of nevi, where individuals with lighter skin have more nevi than those with darker skin. Melanoma is the most malignant skin and mucosal tumor prone to early metastasis. It ranks fifth in terms of frequency in men and seventh in women. The most important factors for a good survival rate are early diagnosis and early treatment. Therefore, regular self-examination of the skin according to the ABCDE rule is highly, along with known sun protection measures. Nurses/technicians play a key role in encouraging people to regularly self-examine nevi following the ABCDE rule in order to educate them and stimulate responsible health behavior. With the increasing incidence of melanoma worldwide, education about responsible health behavior and promoting regular self-examination of pigment changes is an important area of work for dermatologists but also for nurses/technicians. A study was conducted among third-year students at the University North, both in healthcare and non-healthcare fields, investigatig they knowledge about the importance of skin self-examination and recognizing pigment changes. Nurses and dermatologists have a crucial role in raising awareness about regular examinations and skin self-examination among students, with the goal of reducing the incidence of the most malignant skin cancer.