Prostate cancer is one of the most common malignant tumors in men worldwide. Considering the significant impact of this oncological disease on public health, great importance is attached to perioperative care to ensure an optimal outcome during surgical treatment. This paper explores in detail various aspects of perioperative care of patients with prostate cancer. It will analyze the epidemiology, etiology and risk factors associated with prostate cancer. Emphasis is placed on the importance of early detection and adequate diagnostic methods that enable proper classification of the disease. Emphasis will also be placed on the perioperative period, which includes the preparation of the patient for surgery. Emphasis is placed on the importance of a multidisciplinary approach, which includes patient education, comorbidity optimization and psychological support. Also, modern anesthesia techniques and surgical techniques that contribute to reducing complications during surgery are considered. The postoperative period plays a key role in the patient's recovery, therefore special attention is paid to pain control, prevention of complications and early rehabilitation. Monitoring and follow-up of patients after surgery is crucial for early detection of recurrence or other possible problems. The importance of continuous long-term care of patients with prostate cancer after the perioperative period. The inclusion of rehabilitation programs, monitoring of health status and psychological support contribute to improving the quality of life of patients and reducing disease recurrence. In conclusion, this paper aims to emphasize the importance of comprehensive perioperative care of patients with prostate cancer in order to ensure the best possible outcome during surgical treatment and to improve the quality of life of patients and their long-term prognosis.