Intrathecal administration of baclofen has become a critical therapeutic approach for patients with severe spasticity caused by various neurological conditions. This study aimed to gain a deeper understanding of the effects of this therapy on survival, quality of life, and risk of infections in patients with an implanted baclofen intrathecal pump. Professional literature from various sources, including PubMed, HIFA, Hrčak, and relevant medical journals and books, were used to prepare the thesis. Studies and research dealing with using baclofen in intrathecal form in patients with neurological conditions were analyzed. Also, data from the medical history of patients with an implanted IBP on survival, quality of life and incidence of infections were studied. A retrospective approach to medical data analysis was applied to a population of patients receiving baclofen via an implanted intrathecal pump. Data include sociodemographic characteristics, primary diagnosis, drug dose, survival, quality of life, and incidence and type of infection. The analysis was carried out over a multi-year period (2016-2023). Significant results were obtained by analyzing the data. A positive impact of intrathecal baclofen administration on the reduction of spasticity and improvement of patients' functionality was determined. The incidence of infections was high, indicating a relatively high risk of infection. Long-term follow-up showed a fatal outcome in some patients, which indicates potential risks and the need for further research. This retrospective analysis provided a deeper understanding of the effect of intrathecal baclofen administration. Patients with an implanted pump experienced an improvement in quality of life and a reduction in spasticity. The risk of infection is high, but the long-term outcome points to potential challenges. These results support further research and inform the practice of care for patients with severe spasticity. They also have practical implications for medical professionals caring for patients with severe spasticity. Intrathecal administration of baclofen can significantly improve the quality of life of patients, with a relatively high risk of infection. Long-term follow-up of fatal outcomes suggests the need for further research to understand the factors influencing this outcome.