Multiple sclerosis is autoimune degenerative disease that manifest itself trough causing inflamatory processes in the central nervous system. Due to these inflamatory processes, the myelin sheath, which is used for quick and efficient impulse transmission is deteriorating. Precise reason why this happends is still not clarified, but it is assumed that it occurs because of interaction of genetic, imune and enviromental factors. Multiple sclerosis is more common in women and in more developed regions. Three main symptoms that evelop in early stages are nystagmus, chanting speech and intention tremor. Depending on symptoms, desease is classified in four different types: relapsing remititng, primary progressive, secondary progressive and progressive relapsing multiple sclerosis. Manifestation of clinical signs may vary depending on which part of nervous system is affected, but the most common occurrences are spasticity, gait distrurbance, pain, fatigue, urogenital dysfunction, vision impairment and difficulty maintaing balance and coordination. Evoked potentials, magnetic resonance imaging and lumbar puncutre with clinical examination are most commonly used diagostic procedures. Treatment is highly complex and demands multidisciplinary approach. Therapy primarily consists of drug treatment, therapeutic exercises and other auxillary therapeutic procedures. Therapeutic exercises include stretcing exercises, balance exercises and pelvic floor muscule training. Frenkel exercises for improving coordination and proprioception are specially developed for advancing senzorics, coordination and proprioception in neurological patients. These exercises are based on precision, concentration and repetition. They play a major roll in rehabilitation of patients suffering from multiple sclerosis because their main goal is to advance coordination and muscule function which is essential for improving the quality of life and reducing the risk of falling. Other therapeutic tehniques include electrotherapy, hydrotherapy, Seltzer ultrasound, biofeedback, manual massage, Bobath concept and proprioceptive muscular facilitation.