Transfusion is also the clinic and part of laboratory medicine with the task to produce medicines derived from human blood and treating patients with them. This paper presents definitions necessary for the understanding of the work and transfusion science. Blood transfusion is very important voluntary blood because it begins with him and depends on them.There is no production of drugs from the blood without humanity and solidarity of people who is donating it. People give whole blood from which to obtain a separate preparations of red blood cells, platelets, fresh frozen plasma, cryoprecipitate...There are also devices that takes from the donor only one component of blood so production is easier.Giving blood with the donor can lead to mild,medium and heavy side effects.In desire to provide you a better and safer blood products,each dose of blood taken from the donor is tested according to standard operative protocols.All this work is followed by certain documents to be kept permanently. When producing blood component it is necessary to do some tests before applying to patient.The tests are preformed at the units for Transfusion medicine.When they are made and the results are approved by the physician specialist of transfusion,blood component can be transfused to patient.Of course,before and after the additon,there has to be satisfied protocol of written trail about all proceedings. Autoimmune hemolytic anemia is a serious disease of short lifespan of red blood cells in the bloodstream of sick person.It existes several types of AIHA-e so the red blood cells for transfusion are preparing by their characteristics.It is necessary special attention and observation of the patient during transfusion. The nurse works its assessment of the patient and sets diagnosis.She provides nursing care to the patient and performes interventions in accordance with thoose diagnosis.During that job she is using all sorts of scales and patterns and all that is writting down to the nursing documentation. In this paper I presented the case 50 years old patient with autoimmune hemolytic anemia.I described nursing diagnosis,objectives and interventions that can be applied to his case. The transfusion therapy can cause many complications.Some are less well known,some are more.I described complications that are more often and better-known and researched enough so they can be mentioned here.