Resistance to antibiotics is a very important problem of today's community, since discovery of new antibiotics lasts for about 10 years and costs around 300 million dollars. Bacteria can acquire resistance to antibiotics with time and become bacteria with multiple resistance. They have a quick power adjustment DNA, which is developing a new generation of bacteria. Survivor strains transfer their genotype to the next generation of bacteria and develop resistance to antibiotics. It is considered that one-third of antibiotics are unnecessarily prescribed or used antibiotics are not necessary. We must also point out the problem of the presence of residues in food because of the use of the same in plant and animal breeding and the treatment using 50% of all types of antibiotics. The consequences of irrational use in human medicine as well as food consumption with the remains antibiotics leads to increased morbidity, mortality and costs of treatment. The particular risk is their direct toxicity or carcinogenicity, impact on the composition of the gut microflora, possible allergic reactions in sensitive people, and the emergence of some resistance pathogenic microorganisms. The aim of this study is to show the role of antibiotics in the application of human and veterinary medicine and also in agribusiness, and what are the consequences on health due to the irrational application of antibiotics with the help of education health workers and nurses. The role of nurses is education of the population through a system of public health of the general and specific objectives: the rational use of antibiotics, promoting of the healthy lifestyles, prevention and control of infectious diseases, identification and monitoring of antibiotic resistance, early detection of infectious diseases, protection and improvement of health care and health through proper nutrition, healthy food and environmental hygiene.