Aging is a genetically conditioned process that begins with conception and continues until death. Though, aging is not determined only by genetic predisposition because external influences also play an important role in it. While aging, most people also face decrease of immunity. Therefore, older people are often more susceptible to infections and various infectious diseases. Infectious disease occurs due to tissue damage caused by various types of microorganisms. These microorganisms multiply and penetrate into the tissue to produce toxins that adversely affect the organism and cause the onset of infectious disease. During physiological aging, there are many alterations in the body and organs, including the urinary system. Numerous changes result in weakening and impairment of the function of the organs, in the appearance of various problems and the emergence of urinary tract infections. Urinary tract infections are one of the most common diseases occurring in elderly age. The most common cause of urinary tract infections in older people is E. Coli, which often originates from the patient's intestinal flora and makes 50-85% of the total number of urinary tract infections. Signs and symptoms of urinary tract infections vary depending on the age of the patient and the type of the pathogen that caused the infection. Accordingly, urinary tract infections in elderly people are often asymptomatic. Also, urinary tract infections make up the most of the hospital infections, almost 40% of them. The highest risk factor for urinary infections of the urinary system is the bladder catheterization. Although E. Coli is the most common cause of urinary tract infections in hospitals, there is an increasing number of infections induced by more resistant bacteria such as Klebsiella spp. and Pseudomonas spp. In prevention and treatment of urinary tract infections, as well as hospital infections in elderly people, nurse plays very important role. Timely recognition of signs and symptoms of newly emerging urinary tract infection is of great importance. The nurse should, therefore, monitor the condition of the patient, observe the symptoms and any changes in his/her condition and inform the doctor of all of the above. In dealing with such patient, nurse should take a holistic approach, know all the specifics and dynamics of the disease and have a wide range of knowledge and skills. The nurse is in constant contact with the patients and can, therefore, detect possible complications of the illness in time and educationally act on their appearance. The objective of this paper is to describe changes of aging human body, to describe the etiology, diagnosis, treatment and prevention of urinary tract infections within elderly people, to explain the role of the nurse and to specify diagnosis that can be conducted by nurses in such patients.