Cardiovascular diseases (CVD) are a major public health problem in the world and in Croatia. It is estimated that around 19 million people worldwide die annually from some form of cardiovascular disease. Coronary artery disease is the most common cause of death. Acute coronary syndrome (ACS) as a complication of coronary disease is a condition that occurs due to acute obstruction of the coronary artery and inadequate blood supply to the heart muscle. ACS includes unstable angina pectoris and acute myocardial infarction, which as emergency conditions, require rapid recognition, care and treatment. There are numerous factors that influence the development of ACS. We distinguish between modifiable (hypertension, diabetes, dyslipidemia, smoking, overweight) and non-modifiable (age, gender, genetic predisposition) risk factors. Modification and regulation of risk factors can delay the onset of disease, prevent complications, improve treatment, recovery and quality of life. Nurses/technicians have an important role in educating patients about a healthy lifestyle, methods of preventing the occurrence or regulating the risk of variable factors in order to improve the quality of life and the absence of unwanted outcomes of ACS. The aim of this thesis is to assess the extent to which certain risk factors are present in patients diagnosed with ACS, and what is the distribution of risk factors according to gender. Data for this research were collected from the hospital information system of the Klinika za kardiovaskularne bolesti „Magdalena“. The data were collected from medical records in the period from 01.01. – 31.12.2022. The total number of respondents in this research is 100 (N=100). The following conclusions were drawn from the analysis of the obtained results: there are no significant statistical differences between the number of risk factors for the occurrence of ACS in men compared to women, in most patients there were at most two to three risk factors, hypertension and high BMI are the most common risk factors in both gender, diabetes and dyslipidemia are more common in female subjects, while smoking is more prevalent in male subjects.