This paper depicts the basic institutional support of entrepreneurship in the Republic of Croatia with a special emphasis on Međimurje County through access to financial resources, regulatory environment, internationalization, education of entrepreneurs and promotion of entrepreneurship. The beginning of the paper talks generally about the characteristics of entrepreneurship in Croatia over the macroeconomic indicators and presents key national institutions for the support of entrepreneurship. Access to funds is a chapter that discusses ways to finance business projects and displays supporting programs of four most active institutions: the Ministry of Economy, Entrepreneurship and Crafts, the Croatian Bank for Reconstruction and Development, HAMAG-BICRO and the Croatian Employment Service. The fourth chapter discusses the regulatory environment and creating regulations important for small and medium enterprises, as well as establishment and legal work of business entities. The fifth chapter, the internationalization of entrepreneurship, talks about access to information on cross-border business opportunities for medium and small entrepreneurs. The sixth chapter describes the education of entrepreneurship with aim to prepare people for an entrepreneurial career, accepting risk, lifelong learning, running a business, organizing, teamwork, projects and leaders. Chapter seven deals with the promotion of entrepreneurship as an important factor in the development of an entrepreneurial climate. The last chapter gives examples of institutional support of entrepreneurship in Međimurje County.