Adolescents go through biological, physical and psychosocial changes, including experiencing their sexuality. Sexuality is a very important part of adolescence and there is a lot of research into it that can lead to risky sexual behavior and its consequences. Sexually transmitted infections are on the rise among adolescents and are one of the biggest public health problems in the world. A nurse is an active member of the community who, with her work and competences, can contribute to raising awareness of the importance of primary prevention in healthcare and the promotion of health itself through various educations of the healthy population. The main role of the master's degree in nursing is the possibility of creating preventive health care and control of the health care process, providing high-quality evidence-based nursing care accessible to all. One of the priority goals in promoting and preserving the sexual and reproductive health of adolescents, their families as well as the entire community is a positive approach to sexuality, sexual education and education that is not based on judgments. Sexuality is an integral part of human existence, therefore it is extremely important to implement a holistic approach adapted to all ages in the provision of information, education and upbringing. This research aims to analyze the level of knowledge and attitudes of adolescents from urban and rural areas about sexually transmitted infections. In this research, it will be examined whether there are differences in entering sexual relations with regard to the gender of adolescents, it will be examined whether there are differences in knowledge about sexually transmitted infections, it will be examined whether there are differences in knowledge about contraceptive methods, it will be examined whether there are differences in opinions about the need to implement health education in schools with regard to the gender of the respondents. A questionnaire via the Facebook group "Graduate students 2021/2022. the knowledge of high school graduates about sexually transmitted infections was analyzed. The survey was conducted via an online Google form between 14.06. and 31.07.2022. year, and consisted of 31 questions divided into 4 parts. Survey questions include sociodemographic data, experience in sexual relations, questions about contraception, knowledge, attitudes and behavior patterns of adolescents. Out of a total of 270 respondents in the research, 85.2% of respondents are female, and only 14.8% are male. Most respondents are from the city, 58.1%. The most common age of first sexual intercourse is at the age of 16-17 (24.4%), and the condom is most often used as a contraceptive method (52.6%). After the first sexual intercourse, 68.4% of the respondents did not visit a gynecologist. Adolescents get the most knowledge about sexually transmitted infections from the media and the Internet (64.3%), and 70.1% of them believe that through health education they would get more knowledge about sexually transmitted infections and therefore behave more responsibly sexually.