Venous diseases are common in adult population. Such vein-related problems refers to a venous dilation (varicosities), superficial thrombophlebitis, deep vein thrombosis and post-thrombotic syndrome, also called chronic venous insufficiency. Presented etiology and pathophysiology, clinical presentation, diagnosis, treatment, prevention and clinical nursing management of deep vein thrombosis. Venous diseases are common in adult population. Such vein-related problems refers to a venous dilation (varicosities), superficial thrombophlebitis, deep vein thrombosis and post-thrombotic syndrome, also called chronic venous insufficiency. Presented etiology and pathophysiology, clinical presentation, diagnosis, treatment, prevention and clinical nursing management of deep vein thrombosis. The most important DVT management goal is prevention, notwithstanding diagnosis and treatment are of great importance. Identifying patients at risk and adequate prophylactic management improve clinical outcomes and reduce healthcare costs. Health practitioners have a significant role in DVT risk assessment, planning, implementation and evaluation of patient care programes and consequently make a major difference in DVT prevention and treatment outcome.