Amputation represents a surgical process that involves a removal of an injured or diseased part of the body with the end-goal of saving a patient’s life. Factors influencing the indications in this process are quality of life, access to health care, human factors, religious and/or cultural reasons. In any case, movement is a basic human need; hence, the re-establishment of this function is an important aim of the rehabilitation process. For humane and functional reasons, it is pivotal to do everything possible in order to enable people with limb amputation to move in their own environment again. Complications in people with amputations most often include technical difficulties and problems with stump shaping, as well as complications caused by the general condition of the patient. Stump infections after amputation are common and may necessitate re-amputation, opening the door for further serious complications. Rehabilitation includes a range of treatment approaches that aim to maximize individual abilities, reduce addiction, and improve quality of life after a disability. Rehabilitation of a person with amputation includes all interventions that can help patients to familiarize with their prostheses, and in overcoming the complications that accompany their usage, and naturally, to enable them to return to their quotidian life and work. Planning a rehabilitation schedule is, thus, important for an individual with an amputation to overcome complications and become independent, identifying their needs as soon as possible.