Despite the fact that medicine has advanced significantly, nosocomial infections are still ubiquitous in healthcare. Although efforts are being made to end them in all possible ways, they are becoming more frequent and their number is growing every year, especially in the intensive care unit, where are patients who are often immunocompromised and predisposed to infections. Infections further increase and aggravate the complications of the disease of the most endangered patients and it can be said that they are one of the main causes of mortality. Despite the high mortality rate of individual infections, in certain cases they do not represent the sole cause of death, but result in a severe clinical picture of the patient for which the patient was initially hospitalized. Hospital infection rates are an extremely important indicator of health quality. Since they represent one of the biggest problems in health care, they are an important segment of assessing the quality of service and care in the health system. A well-organized infection control system is an important means of combating this, but also limiting its effect. It is extremely important to regularly educate health and non-health professionals regarding the prevention and prevention of infections and to implement a risk management strategy, which requires processes of comparison with the best standards of practice. As in all other institutions and strategies, the basic principles of work, its quality and protection against risk are set within this strategy. That means that, first of all, it is necessary to define and carry out risk identification, then conduct assessment and analysis, and, at the very end, implement change and strive to constantly work on improvements. In intensive care unit (ICU), the development of nosocomial infections may be associated with a complication of underlying non-communicable diseases or intensive care procedures for patients. The basis of the work of all health professionals is the protection of patients and themselves, given that nosocomial infections are a daily occurrence and their prevention is a part of everyday medical work. ICUs play a significant role in the incidence of nosocomial infections due to the use of a large number of invasive diagnostic and therapeutic methods.