Percutaneous endoscopic gastrostomy (PEG) is defined as a medical procedure, i.e. a method used to insert a feeding tube directly into the stomach through the abdominal wall. Percutaneous endoscopic gastrostomy is used in patients who cannot swallow properly due to various medical conditions (after suffering brain injuries, neurological diseases, in case of chronic loss of appetite as in diseases such as tumors). Nursing care for patients with a PEG tube, which is placed through the abdominal wall into the stomach, requires careful and regular assessment to prevent complications and keep the tube in proper condition. The key responsibilities include daily inspection of the PEG tube insertion site for signs of irritation, infection or leakage, as well as cleaning the area around the tube using sterile water or saline solution to prevent fluid buildup and skin damage. Additionally, the nurse must regularly check the position of the tube to ensure it is functioning properly and to prevent the tube from moving out of the desired position. Furthermore, proper feeding and medication administration via the PEG tube must be ensured, which includes checking the prescription for enteral nutrition, flushing the tube before and after use to prevent blockages, and continuously monitoring the patients reactions and symptoms such as bloating or discomfort. In case of complications, the nurse should immediately inform the doctor so that a timely response and adjustment of the care plan can be made. In addition to the above, the role of the nurse is crucial in providing support to the patient with a PEG tube and his family. She is the main source of information and provider of emotional support to the patient. The aim of the paper is to identify and describe in detail the specific challenges and care protocols related to PEG tube management, as well as to develop guidelines for improving the quality of care and treatment results in these patients, with an emphasis on maintaining the functionality of the tube, preventing infections and ensuring adequate nutritional and emotional support.